Fluorinated dihydroquinolines as potent n-NOS inhibitors

Stefan Jaroch; Hartmut Rehwinkel; Peter Hölscher; Detlev Sülzle; Gerardine Burton; Margrit Hillmann; Fiona M McDonald; Heribert Miklautz

doi:10.1016/j.bmcl.2003.11.022

Fluorinated dihydroquinolines as potent n-NOS inhibitors

Bioorg Med Chem Lett. 2004 Feb 9;14(3):743-6. doi: 10.1016/j.bmcl.2003.11.022.

Authors

Stefan Jaroch¹, Hartmut Rehwinkel, Peter Hölscher, Detlev Sülzle, Gerardine Burton, Margrit Hillmann, Fiona M McDonald, Heribert Miklautz

Affiliation

¹ Medicinal Chemistry, Corporate Research, Research Center Europe, Schering AG, D-13342-Berlin, Germany. stefan.jaroch@schering.de

PMID: 14741281
DOI: 10.1016/j.bmcl.2003.11.022

Abstract

Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (n-NOS) inhibitors are reported.

MeSH terms

Amidines / metabolism*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Fluorine / chemistry*
Nitric Oxide Synthase / antagonists & inhibitors*
Nitric Oxide Synthase Type I
Quinolines / chemistry
Quinolines / pharmacology*
Structure-Activity Relationship

Substances

Amidines
Enzyme Inhibitors
Quinolines
Fluorine
Nitric Oxide Synthase
Nitric Oxide Synthase Type I